Studies on 1,2,4-Triazine Derivatives VI

Abstract

Treatment each of 3-mercapto-1,2,4-triazine derivatives (1 a) and (2b) with alkyl (or aryl) halides afforded the corresponding 3-alkyl (or aryl)mercapto-1,2,4-triazine derivatives (lb-e) and (2b-e) respectively. Treatment each of compounds (lb-e) and (2b-e) with different amines effected the formation of the corresponding 3-substituted-amino-1,2,4-triazine derivatives (lg-k) and (2g-k). The 4,5-dihydro-derivatives (3 a, c, d) were obtained by reduction of the corresponding triazines (la, f, g) with different reducing agents. The structure of compound 3 d was confirmed via synthesis through another route. The triazine (1f) reacted with Grignard reagents to give the corresponding 5-alkyl(benzyl)-4,5-dihydro-1,2,4-triazine derivatives (4a-c). The antagonistic properties of the triazines (1 a-k) and (2 a-k) were tested against some Gram positive and Gram negative bacteria as well as the fungus Candida albicans.