Evaluation of the Influence of thiosemicarbazone–triazole hybrids on genes implicated in lipid oxidation and accumulation as potential anti-obesity agents

Adipose Expression of Tumor Necrosis Factor-α: Direct Role in Obesity-Linked Insulin Resistance

Gökhan S. Hotamışlıgil, Narinder S. Shargill, Bruce M. Spiegelman · Science · 1993 · 7.5K citations

Medicine, Endocrinology, Molecular Biology +17

Impaired Mitochondrial Activity in the Insulin-Resistant Offspring of Patients with Type 2 Diabetes

Kitt Falk Petersen, Sylvie Dufour, Douglas E. Befroy et al. · New England Journal of Medicine · 2004 · 2.2K citations · Full text

Life Sciences, Biochemistry, Physiology +17

Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of <i>PGC1</i> and <i>NRF1</i>

Mary‐Elizabeth Patti, Atul J. Butte, Sarah Crunkhorn et al. · Proceedings of the National Academy of Sciences · 2003 · 1.9K citations · Full text

Medicine, Molecular Genetics, Physiology +17

Peroxisome Proliferator-activated Receptor-γ Co-activator 1α-mediated Metabolic Remodeling of Skeletal Myocytes Mimics Exercise Training and Reverses Lipid-induced Mitochondrial Inefficiency

Timothy R. Koves, Ping Li, Jie An et al. · Journal of Biological Chemistry · 2005 · 464 citations · Full text

Life Sciences, Biochemistry, Physiology +17

Overexpression of Carnitine Palmitoyltransferase-1 in Skeletal Muscle Is Sufficient to Enhance Fatty Acid Oxidation and Improve High-Fat Diet–Induced Insulin Resistance

Clinton R. Bruce, Andrew J. Hoy, Nigel Turner et al. · Diabetes · 2008 · 364 citations · Full text

Life Sciences, Biochemistry, Physiology +17