A position- and orientation-dependent element in the first intron is required for expression of the mouse hprt gene in embryonic stem cells

Targeted disruption of the c-src proto-oncogene leads to osteopetrosis in mice

Philippe Soriano, Charles A. Montgomery, Robert S. Geske et al. · Cell · 1991 · 2K citations

Sclerostin, Developmental Biology, Bone Morphogenic Protein +7

A lymphocyte-specific cellular enhancer is located downstream of the joining region in immunoglobulin heavy chain genes

Julian Banerji, Laura Olson, Walter Schaffner · Cell · 1983 · 1.5K citations

Immunogenetics, Immunology, Antigen Processing +6

Promoter-specific activation of RNA polymerase II transcription by Sp1

James T. Kadonaga, Katherine A. Jones, Robert Tjian · Trends in Biochemical Sciences · 1986 · 1.1K citations

Promoter-specific Activation, Transcriptional Regulation, Genetics +5

Introns increase transcriptional efficiency in transgenic mice.

Ralph L. Brinster, J M Allen, Richard R. Behringer et al. · Proceedings of the National Academy of Sciences · 1988 · 732 citations · Full text

Knockout Mouse, Transcriptional Regulation, Murine Germ Line +13

GENETICS OF HUMAN CELL LINES, IV. DNA-MEDIATED HERITABLE TRANSFORMATION OF A BIOCHEMICAL TRAIT

Elizabeth Hunter Szybalska, Waclaw Szybalski · Proceedings of the National Academy of Sciences · 1962 · 496 citations · Full text