David W. Melton

Targetted correction of a mutant HPRT gene in mouse embryonic stem cells

Thomas Doetschman, Ronald G. Gregg, Nobuyo Maeda et al. · Nature · 1987 · 790 citations

Embryonic Stem Cell, Developmental Biology, Mutant Hprt Gene +8

Ataxia in prion protein (PrP)-deficient mice is associated with upregulation of the novel PrP-like protein doppel

Richard C. Moore, Inyoul Y. Lee, Gregory L. Silverman et al. · Journal of Molecular Biology · 1999 · 519 citations

Knockout Mouse, Creutzfeldt-jakob Disease, Medicine +9

Structure, expression, and mutation of the hypoxanthine phosphoribosyltransferase gene.

David W. Melton, David Konecki, John Brennand et al. · Proceedings of the National Academy of Sciences · 1984 · 431 citations · Full text

Biosynthesis, Functional Genomics, Biochemistry +15

Germ line transmission and expression of a corrected HPRT gene produced by gene targeting in embryonic stem cells

Simon Thompson, Alan R. Clarke, Angela M. Pow et al. · Cell · 1989 · 425 citations

Developmental Biology, Health Sciences, Germ Line Transmission +13

Mice with DNA repair gene (ERCC-1) deficiency have elevated levels of p53, liver nuclear abnormalities and die before weaning

Jim McWhir, Jim Selfridge, David J. Harrison et al. · Nature Genetics · 1993 · 320 citations

Knockout Mouse, Dna Repair Gene, Genome Instability +9