Concepedia

Inhibition of thioredoxin-1 with siRNA exacerbates apoptosis by activating the ASK1-JNK/p38 pathway in brain of a stroke model rats

Xiaoying Wu, Lingyu Li, Luyu Zhang, Jingxian Wu, Yunchuan Zhou, Yang Zhou, Yong Zhao, Jing Zhao

Brain Research · 2014 · 52 citations · 29 references

DOI

Concepts

References

29

Reversible middle cerebral artery occlusion without craniectomy in rats.

Enrique Zea Longa, Philip R. Weinstein, Shaun W. Carlson et al. · Stroke · 1989 · 7.5K citations · Full text

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Mammalian thioredoxin is a direct inhibitor of apoptosis signal‐regulating kinase (ASK) 1

Masao Saitoh · The EMBO Journal · 1998 · 2.4K citations · Full text

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Induction of Apoptosis by ASK1, a Mammalian MAPKKK That Activates SAPK/JNK and p38 Signaling Pathways

Hidenori Ichijo, Eisuke Nishida, Kenji Irie et al. · Science · 1997 · 2.3K citations

, , +16

Thioredoxin and Glutaredoxin Systems

Arne Holmgren · Journal of Biological Chemistry · 1989 · 1.8K citations · Full text

, , +8

ASK1 is required for sustained activations of JNK/p38 MAP kinases and apoptosis

Kei Tobiume, Atsushi Matsuzawa, Takumi Takahashi et al. · EMBO Reports · 2001 · 1.2K citations · Full text

, , +13