Design, synthesis, and in vitro evaluation of inhibitors of human leukocyte elastase based on a functionalized cyclic sulfamide scaffold

The determination of enzyme inhibitor constants

Martin Dixon · Biochemical Journal · 1953 · 4.1K citations · Full text

Life Sciences, Biochemistry, Biochemical Pharmacology +15

Neutrophil elastase and acute lung injury: Prospects for sivelestat and other neutrophil elastase inhibitors as therapeutics

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Structure-Based Design of a General Class of Mechanism-Based Inhibitors of the Serine Proteinases Employing a Novel Amino Acid-Derived Heterocyclic Scaffold

William C. Groutas, Rongze Kuang, R. Venkataraman et al. · Biochemistry · 1997 · 79 citations

Pharmacy, Medicinal Chemistry, Pharmacology +16

The prognostic value of polymorphonuclear leukocyte elastase in patients with primary breast cancer.

John A. Foekens, Christian Ries, Maxime P. Look et al. · PubMed · 2003 · 68 citations · Full text

Medicine, Cancer Biology, Oncology +16

Combinatorial Strategies for Targeting Protein Families: Application to the Proteases

Dustin J. Maly, Lily Huang, Jonathan A. Ellman · ChemBioChem · 2002 · 64 citations

Life Sciences, Biochemistry, Molecular Biology +13