Design and Synthesis of Novel Artemisinin‐Like Ozonides with Antischistosomal Activity

Abstract

Abstract To develop new drugs for prevention and treatment of schistosomiasis, a series of novel artemisinin‐like ozonides 10 were synthesized via a facile three‐step procedure starting with the degraded product of artemisinin ( Scheme ). The Criegee ozonolysis reaction of the unsaturated lactone intermediates 14 is the key step which provided the target molecules 10 . The in vivo pharmacological results suggested that this type of artemisinin analogues exhibited moderate antischistosomal activity ( Table ).