Regulation of α- and β-secretase activity by oxysterols: Cerebrosterol stimulates processing of APP via the α-secretase pathway

β-Secretase Cleavage of Alzheimer's Amyloid Precursor Protein by the Transmembrane Aspartic Protease BACE

Robert Vassar, Brian D. Bennett, Safura Babu‐Khan et al. · Science · 1999 · 3.8K citations · Full text

Life Sciences, Biochemistry, Molecular Biology +17

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

Bart De Strooper, Paul Säftig, Katleen Craessaerts et al. · Nature · 1998 · 1.8K citations

Life Sciences, Molecular Biology, Neuroscience +15

Constitutive and regulated α-secretase cleavage of Alzheimer’s amyloid precursor protein by a disintegrin metalloprotease

Sven Lammich, Elżbieta Kojro, Rolf Postina et al. · Proceedings of the National Academy of Sciences · 1999 · 1.1K citations

Life Sciences, Biochemistry, Molecular Biology +17

Structural requirements of ligands for the oxysterol liver X receptors LXRα and LXRβ

Bethany A. Janowski, Michael J. Grogan, Stacey A. Jones et al. · Proceedings of the National Academy of Sciences · 1999 · 937 citations

Life Sciences, Biochemistry, Pharmacology +14

Cholesterol homeostasis in human brain: evidence for an age-dependent flux of 24S-hydroxycholesterol from the brain into the circulation.

Dieter Lütjohann, Olof Breuer, G. Ahlborg et al. · Proceedings of the National Academy of Sciences · 1996 · 675 citations · Full text

Life Sciences, Biochemistry, Physiology +7