Concepedia

AM1 study of structure-activity relationships in bicyclic aza-β-lactams

Ashwini Nangia, P. S. Chandrakala, M.V. Balaramakrishna, T.V.A. Latha

Journal of Molecular Structure THEOCHEM · 1995 · 14 citations · 27 references

Concepts

PharmacyChemistryMedicinal ChemistryDrug DesignDrug DiscoveryStructure-activity RelationshipsBeta-lactam ResistanceChemical Library DesignLigand-based DesignQualitative Structure-activity RelationshipsQuantitative Structure-activity RelationshipsStructure-activity Relationship AnalysisBeta-lactamase Structure-function RelationshipsChemical Structure-activity RelationshipsLactam MacrocyclesSar InterpretationSpectrum Of Beta-lactam AntibioticsStructure - Activity Relationship Optimizationβ-Lactam Antibiotics

References

27

Development and use of quantum mechanical molecular models. 76. AM1: a new general purpose quantum mechanical molecular model

Michael J. S. Dewar, Eve G. Zoebisch, Eamonn F. Healy et al. · Journal of the American Chemical Society · 1985 · 13.1K citations

Natural Sciences, Chemistry, Physics +10

Recent Developments in the Field of β‐Lactam Antibiotics

Walter Dürckheimer, J. BLUMBACH, Rudolf Lattrell et al. · Angewandte Chemie International Edition in English · 1985 · 302 citations

Pharmacy, Medicinal Chemistry, Pharmacokinetics +13

Structure and absolute configuration of thienamycin

G. ALBERS‐SCHOENBERG, Byron H. Arison, Otto D. Hensens et al. · Journal of the American Chemical Society · 1978 · 299 citations

Pharmacy, Chemistry, Medicinal Chemistry +8

Penicillin resistance: the chemistry of .beta.-lactamase inhibition

Jeremy R. Knowles · Accounts of Chemical Research · 1985 · 226 citations

Life Sciences, Medicinal Chemistry, Antimicrobial Pharmacology +13

Molecular architecture of the cephalosporins. Insights into biological activity based on structural investigations

Robert M. Sweet, Lawrence F. Dahl · Journal of the American Chemical Society · 1970 · 131 citations

Pharmacy, Biochemistry, Medicinal Chemistry +10