Protective Role of CD40 in Leishmania major Infection at Two Distinct Phases of Cell-Mediated Immunity

Development of T _H 1 CD4 ⁺ T Cells Through IL-12 Produced by <i>Listeria</i> -Induced Macrophages

Chyi‐Song Hsieh, S E Macatonia, Catherine S. Tripp et al. · Science · 1993 · 3.1K citations

Life Sciences, Immunology, Microbiology +17

Natural killer cell stimulatory factor (interleukin 12 [IL-12]) induces T helper type 1 (Th1)-specific immune responses and inhibits the development of IL-4-producing Th cells.

Roberto Manetti, Paola Parronchi, M G Giudizi et al. · The Journal of Experimental Medicine · 1993 · 1.7K citations · Full text

Life Sciences, Cell Biology, Immunology +17

B7-1 and B7-2 costimulatory molecules activate differentially the Th1/Th2 developmental pathways: Application to autoimmune disease therapy

Vijay K. Kuchroo, Mercy Prabhu Das, Julia A. Brown et al. · Cell · 1995 · 1.7K citations · Full text

Life Sciences, Immunology, Molecular Biology +15

Reciprocal expression of interferon gamma or interleukin 4 during the resolution or progression of murine leishmaniasis. Evidence for expansion of distinct helper T cell subsets.

Frederick P. Heinzel, M D Sadick, B J Holaday et al. · The Journal of Experimental Medicine · 1989 · 1.5K citations · Full text

Veterinary Medicine, Immunology, Infectious Diseases +17

Altered immune responses in mice lacking inducible nitric oxide synthase

Xiaoqing Wei, Ian G. Charles, Austin Smith et al. · Nature · 1995 · 1.3K citations

Life Sciences, Immunology, Immunoregulation +13