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Acetylation of pregnane X receptor protein determines selective function independent of ligand activation

Arunima Biswas, Danielle Pasquel, Rakesh K. Tyagi, Sridhar Mani

Biochemical and Biophysical Research Communications · 2011 · 60 citations · 13 references

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13

Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan

Konrad T. Howitz, Kevin J. Bitterman, Haim Cohen et al. · Nature · 2003 · 3.8K citations

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Stress-Dependent Regulation of FOXO Transcription Factors by the SIRT1 Deacetylase

Anne Brunet, Lora B. Sweeney, James Fitzhugh Sturgill et al. · Science · 2004 · 3.2K citations

, , +15

An Orphan Nuclear Receptor Activated by Pregnanes Defines a Novel Steroid Signaling Pathway

Steven A. Kliewer, John T. Moore, Laura Wade et al. · Cell · 1998 · 1.5K citations · Full text

, , +16

Inhibition of Silencing and Accelerated Aging by Nicotinamide, a Putative Negative Regulator of Yeast Sir2 and Human SIRT1

Kevin J. Bitterman, Rozalyn M. Anderson, Haim Cohen et al. · Journal of Biological Chemistry · 2002 · 998 citations · Full text

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SIRT1 Deacetylates and Positively Regulates the Nuclear Receptor LXR

Xiaoling Li, Songwen Zhang, Gil Blander et al. · Molecular Cell · 2007 · 625 citations · Full text

, , +11