Preparation, analysis and antibody binding studies of simultaneously synthesized soluble and cellulose-bound HIV-1 p24 peptide epitope libraries

General method for the rapid solid-phase synthesis of large numbers of peptides: specificity of antigen-antibody interaction at the level of individual amino acids.

Richard A. Houghten · Proceedings of the National Academy of Sciences · 1985 · 1.7K citations · Full text

Life Sciences, Biochemistry, Molecular Biology +14

Use of peptide synthesis to probe viral antigens for epitopes to a resolution of a single amino acid.

H. Mario Geysen, Rob H. Meloen, S J Barteling · Proceedings of the National Academy of Sciences · 1984 · 1.5K citations · Full text

Life Sciences, Biochemistry, Immunology +17

Measurements of the true affinity constant in solution of antigen-antibody complexes by enzyme-linked immunosorbent assay

Bertrand Friguet, Alain Chaffotte, Lisa Djavadi‐Ohaniance et al. · Journal of Immunological Methods · 1985 · 1.2K citations

Life Sciences, Biochemistry, Immunology +15

Spot-synthesis: an easy technique for the positionally addressable, parallel chemical synthesis on a membrane support

Ronald Frank · Tetrahedron · 1992 · 1.1K citations

Engineering, Chemical Engineering, Chemistry +4

Peptide-binding specificity of the molecular chaperone BiP

Gregory C. Flynn, Jan Pohl, Mark T. Flocco et al. · Nature · 1991 · 773 citations

Life Sciences, Biochemistry, Molecular Biology +14