Studies on drug‐induced lipodosis (V). Changes in the lipid composition of rat liver and spleen following the administration of 4,4′‐diethylaminoethoxyhexestrol

Abstract

Abstract Administration of 4,4′‐diethylamino‐ethoxyhexestrol increased total phospholipids and free cholesterol in rat liver. An elevation of a peculiar glycerophospholipid, lysobisphosphatidic acid, was marked both in liver and spleen. An increase in phosphatidylinositol was also noticed in spleen. However these changes in rats were not so marked as in human cases. There was an accumulation of a substance in rat tissue which was identified as a derivative of the drug, while the intact drug accumulated in large amount in human cases. Differences in the effect of 4,4′‐diethylaminoethoxyhexestrol on lipid metabolism between human and rat seem to be related to the difference in drug digesting ability between these two animal species.