Concepedia

Asymmetric synthesis of the 6-cyanoindole derivatives as non-steroidal glucocorticoid receptor modulators using (+)- and (−)-tert-butyl 6-cyano-3-[3-ethoxy-1,1,1-trifluoro-2-hydroxy-3-oxopropan-2-yl]-1H-indole-1-carboxylate

Takaaki Sumiyoshi, Kengo Tojo, Daisuke Urabe, Masanori Tobe

Tetrahedron Asymmetry · 2011 · 10 citations · 19 references

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Concepts

References

19

Catalytic asymmetric synthesis

Choice Reviews Online · 2001 · 2.7K citations

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Dissociation of transactivation from transrepression by a selective glucocorticoid receptor agonist leads to separation of therapeutic effects from side effects

Heike Schäcke, Arndt Schottelius, Wolf‐Dietrich Döcke et al. · Proceedings of the National Academy of Sciences · 2003 · 470 citations · Full text

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Asymmetric Organocatalysis

K. N. Houk, Benjamin List · Accounts of Chemical Research · 2004 · 449 citations

, , +6

Cinchona Alkaloids in Asymmetric Organocatalysis

Tommaso Marcelli, Henk Hiemstra · Synthesis · 2010 · 421 citations

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Catalytic, Highly Enantioselective Friedel−Crafts Reactions of Aromatic and Heteroaromatic Compounds to Trifluoropyruvate. A Simple Approach for the Formation of Optically Active Aromatic and Heteroaromatic Hydroxy Trifluoromethyl Esters

Wei Zhuang, Nicholas Gathergood, Rita G. Hazell et al. · The Journal of Organic Chemistry · 2001 · 191 citations · Full text

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