Suppressed severity of collagen-induced arthritis by in vivo transfection of nuclear factor ?B decoy oligodeoxynucleotides as a gene therapy

Abstract

The present results demonstrate that administration of NF-kappaB decoy ODN in arthritic joints of rats with CIA led to an amelioration of arthritis. These findings suggest that intraarticular transfection of NF-kappaB decoy ODN may provide a useful therapeutic approach for the treatment of inflammatory arthritis.