Inhibition of P-glycoprotein Activity at the Primate Blood-Brain Barrier Increases the Distribution of Nelfinavir into the Brain but Not into the Cerebrospinal Fluid

The drug transporter P-glycoprotein limits oral absorption and brain entry of HIV-1 protease inhibitors.

Richard B. Kim, Martin F. Fromm, Christoph Wandel et al. · Journal of Clinical Investigation · 1998 · 1.1K citations · Full text

Oral Bioavailability, Immunology, Pharmacotherapy +17

Changes to AIDS dementia complex in the era of highly active antiretroviral therapy

Gregory J. Dore, Patricia Correll, Yueming Li et al. · AIDS · 1999 · 420 citations

Alzheimer's Disease, Human Retrovirus, Aids Dementia Complex +17

Relationship between human immunodeficiency virus—associated dementia and viral load in cerebrospinal fluid and brain

Justin C. McArthur, Daniel McClernon, Michael F. Cronin et al. · Annals of Neurology · 1997 · 399 citations

Pharmacological Inhibition of P-glycoprotein Transport Enhances the Distribution of HIV-1 Protease Inhibitors into Brain and Testes

Edna F. Choo, Brenda F. Leake, Christoph Wandel et al. · Drug Metabolism and Disposition · 2000 · 394 citations · Full text

Reversal of P-glycoprotein-mediated multidrug resistance by a potent cyclopropyldibenzosuberane modulator, LY335979.

Anne H. Dantzig, Robert L. Shepard, Jin Cao et al. · PubMed · 1996 · 327 citations

Pharmaceutical Science, Pharmacotherapy, Chemical Biology +19