Determining target engagement in living systems

A Stepwise Huisgen Cycloaddition Process: Copper(I)-Catalyzed Regioselective “Ligation” of Azides and Terminal Alkynes

Vsevolod V. Rostovtsev, Luke G. Green, Valery V. Fokin et al. · Angewandte Chemie International Edition · 2002 · 11.5K citations

Natural Sciences, Chemistry, Catalysis +8

Cell Surface Engineering by a Modified Staudinger Reaction

Eliana Saxon, Carolyn R. Bertozzi · Science · 2000 · 2.4K citations

Life Sciences, Biochemistry, Bioengineering +17

The Bruton tyrosine kinase inhibitor PCI-32765 blocks B-cell activation and is efficacious in models of autoimmune disease and B-cell malignancy

Lee Honigberg, Ashley M. Smith, Mint Sirisawad et al. · Proceedings of the National Academy of Sciences · 2010 · 1.5K citations · Full text

Life Sciences, Immunology, Pharmacology +17

Activity-based protein profiling: The serine hydrolases

Yongsheng Liu, Matthew P. Patricelli, Benjamin F. Cravatt · Proceedings of the National Academy of Sciences · 1999 · 1.1K citations

Life Sciences, Biochemistry, Molecular Biology +16

Bruton Tyrosine Kinase Inhibitor Ibrutinib (PCI-32765) Has Significant Activity in Patients With Relapsed/Refractory B-Cell Malignancies

Ranjana H. Advani, Joseph J. Buggy, Jeff P. Sharman et al. · Journal of Clinical Oncology · 2012 · 1.1K citations · Full text

Medicine, Oncology, Pharmacology +17