Concepedia

Inhibition of dimethylnitrosamine-induced liver fibrosis by [5-(2-pyrazinyl)-4-methyl-1,2-dithiol-3-thione] (oltipraz) in rats: suppression of transforming growth factor-β1 and tumor necrosis factor-α expression

Keon Wook Kang, Sung Hee Choi, Jong Ryul Ha, Choon Won Kim, Sang Geon Kim

Chemico-Biological Interactions · 2002 · 26 citations · 31 references

DOI

Concepts

References

31

Cytochrome P450 2E1 and 2A6 enzymes as major catalysts for metabolic activation of <i>N</i>-nitrosodialkylamines and tobacco-related nitrosamines in human liver microsomes

Hiroshi Yamazaki, Yukiharu Inui, Chul‐Ho Yun et al. · Carcinogenesis · 1992 · 399 citations

, , +13

<i>In vivo</i> inhibition of rat stellate cell activation by soluble transforming growth factor β type II receptor: A potential new therapy for hepatic fibrosis

Jacob George, Dominique Roulot, Victor Koteliansky et al. · Proceedings of the National Academy of Sciences · 1999 · 322 citations · Full text

, , +17

Blockade of type β transforming growth factor signaling prevents liver fibrosis and dysfunction in the rat

Zhe Qi, Nobuhiko Atsuchi, Akira Ooshima et al. · Proceedings of the National Academy of Sciences · 1999 · 289 citations

, , +15

Hepatic fibrosis, glomerulosclerosis, and a lipodystrophy-like syndrome in PEPCK-TGF-beta1 transgenic mice.

David E. Clouthier, Sarah A. Comerford, Robert E. Hammer · Journal of Clinical Investigation · 1997 · 283 citations · Full text

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Mechanism of protection against aflatoxin tumorigenicity in rats fed 5-(2-pyrazinyl)-4-methyl-1,2-dithiol-3-thione (oltipraz) and related 1,2-dithiol-3-thiones and 1,2-dithiol-3-ones.

Thomas W. Kensler, Patricia A. Egner, Patrick M. Dolan et al. · PubMed · 1987 · 242 citations

, , +14