RelA/p65 functions to maintain cellular senescence by regulating genomic stability and DNA repair

Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis

Zhenbang Chen, Lloyd C. Trotman, David R. Shaffer et al. · Nature · 2005 · 2K citations · Full text

Cell Regulation, Pten-deficient Tumorigenesis, Crucial Role +10

Reversal of human cellular senescence: roles of the p53 and p16 pathways

Christian Beauséjour · The EMBO Journal · 2003 · 1.4K citations · Full text

Developmental Biology, Anti-aging, Aging +8

Both Rb/p16INK4a inactivation and telomerase activity are required to immortalize human epithelial cells

Tohru Kiyono, Scott A. Foster, Jenn I. Koop et al. · Nature · 1998 · 1.2K citations

Developmental Biology, Cell Regulation, Rb/p16ink4a Inactivation +8

Oncogene-induced senescence as an initial barrier in lymphoma development

Melanie Braig, Soyoung Lee, Christoph Loddenkemper et al. · Nature · 2005 · 1.2K citations

Tumor Biology, Lymphoid Neoplasia, Oncogenic Agent +5

IKKβ Couples Hepatocyte Death to Cytokine-Driven Compensatory Proliferation that Promotes Chemical Hepatocarcinogenesis

Shin Maeda, Hideaki Kamata, Jun‐Li Luo et al. · Cell · 2005 · 1.2K citations · Full text

Inflammation, Signal Transduction, Hepatology +13