Facile One-Pot, Multicomponent Synthesis of Pyridines Under Microwave Irradiation

Abstract

Abstract A series of 2-amino-6-(2-oxo-2H-chromen-3-yl)-4-pyridine-3-carbo-nitriles were synthesized by the one-pot, multicomponent reaction of 3-acetyl-coumarin, aromatic aldehydes, malononitrile, and ammonium acetate in acetic acid under microwave irradiation. The reactions were completed in 10–13 min with 61–86% yields, were environmental benign, and had easy workup. Their structures were confirmed by 1H NMR, IR, and MS spectra and elemental analysis. Keywords: 3-Acetylcoumarin2-amino-6-(2-oxo-2H-chromen-3-yl)-4-pyridine-3-carbonitrilemicrowave irradiationmulticomponent reaction ACKNOWLEDGMENT We thank the Jiangsu Key Laboratory for Chemistry of Low-Dimensional Materials for financial support (JSKC07041). Notes a Yields of the isolated products.