Chemistry Letters · 1995 · 94 citations · 11 references
MedicinePharmacologyStructure-activity RelationshipsLigand BindingReceptor PharmacologyAssociation ConstantsPhosphate RecognitionReceptorsSpacer DesignSpacer TechnologyUrea Linkers
Abstract Tris(2-aminoethyl)amine and cis-1,3,5-tris(aminomethyl)cyclohexane have been checked as spacers for phosphate receptors. Ureas are better binding arms than thioureas for these spacers while the combination of this first functional group with chromenone fragments permits further increases in the phosphate and sulfate association constants.
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Peter G. Schultz · Angewandte Chemie International Edition in English · 1989 · 133 citations
Pharmacy, Biotechnology, Immunology +14
Craig S. Wilcox, James C. Adrian, Thomas H. Webb et al. · Journal of the American Chemical Society · 1992 · 120 citations