Second-line chemotherapy with low-dose CPT-11 and cisplatin for colorectal cancer resistant to 5-FU-based chemotherapy

Randomised comparison of combination chemotherapy plus supportive care with supportive care alone in patients with metastatic colorectal cancer.

Werner Scheithauer, Harald Rosén, Gabriela Kornek et al. · BMJ · 1993 · 659 citations · Full text

Medicine, Oncology, Pharmacotherapy +14

Antitumor activity of 7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxy-camptothec in, a novel water-soluble derivative of camptothecin, against murine tumors.

Takehiko Kunimoto, Kazuo Nitta, Takashi Tanaka et al. · PubMed · 1987 · 412 citations

Pharmacy, Medicinal Chemistry, Pharmacology +15

Phase II study of CPT-11, a new camptothecin derivative, in metastatic colorectal cancer. CPT-11 Gastrointestinal Cancer Study Group.

Y. Shimada, Makoto Yoshino, A Wakui et al. · Journal of Clinical Oncology · 1993 · 396 citations

Medicine, Oncology, Pharmacology +15

Oxaliplatin with high-dose leucovorin and 5-fluorouracil 48-hour continuous infusion in pretreated metastatic colorectal cancer

Aimery de Gramont, J. Vignoud, Christophe Tournigand et al. · European Journal of Cancer · 1997 · 385 citations

Medicine, Oncology, Pharmacology +14

DNA topoisomerase I-mediated DNA cleavage and cytotoxicity of camptothecin analogues.

Y H Hsiang, Leroy F. Liu, Monroe E. Wall et al. · PubMed · 1989 · 341 citations

Medicine, Oncology, Pharmacology +13