Phytotherapy Research · 1994 · 23 citations · 6 references
MedicineBiochemistryPharmacologyBioavailabilityFood ChemistryPharmacodynamicsBile Acid MetabolismBile FormationBile SecretionCholesterol MetabolismGastrointestinal PharmacologyLipid MetabolismAnimal Models Of CholestasisBile Acid PharmacologyBile Composition AnalysisBile Flow MeasurementTerpenoid GlycosidesToxicological Analysis Of Bile
Abstract The influence on bile flow of the fruit essence from three chemotypes of the genus Thapsia and their major components has been investigated. For comparative purposes menthol and peppermint oil were also included in the assay. All the drugs tested showed toa different extent choleretic activity calculated on the increase of the bile amount in male adbult Wistar rats. Thapsia Chem I (50 mg/kg) containing 88% geranylacetate was found to indued choleresis in treated rats to a level as high as peppermint oil containing 42% menthol. A similar activity was confirmed when pure geranylacetate was assayed.
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