Michael addition of poly-L-lysine to N-acryloylated sialosides. Syntheses of influenza A virus haemagglutinin inhibitor and group B meningococcal polysaccharide vaccinest

Abstract

N-Acryloylated sialoside derivatives are directly conjugated to poly-L-lysine and protein carriers by the 1,4-conjugate additions of their Nε-lysine residues to provide new glycoconjugates with potential therapeutic utilities.