Concepedia

Molecular amplification in a dynamic combinatorial library using non-covalent interactions

Ricardo L. E. Furlán, Graham R. L. Cousins, Jeremy K. M. Sanders

Chemical Communications · 2000 · 60 citations · 3 references

Concepts

PharmacyChemistryCombinatorial ChemistryDrug DiscoveryMolecular RecognitionDynamic Combinatorial ChemistryLigand BindingAmplificationCombinatorial Library DesignCombinatorial Library ScreeningCombinatorial Library SynthesisCovalent InteractionsDynamic Combinatorial LibrariesNon-covalent InteractionsPeptide Library Design

Abstract

A trace component within a dynamic combinatorial library of pseudo-peptide hydrazones has been dramatically amplified in a reversible manner through recognition by [18]crown-6.

References

3

Guest-Templated Selection and Amplification of a Receptor by Noncovalent Combinatorial Synthesis

Mercedes Crego Calama, Peter Timmerman, David N. Reinhoudt · Angewandte Chemie International Edition · 2000 · 88 citations

Pharmacy, Chemistry, Evolutionary Biology +17

Structures of the 1:1 complexes of 18-crown-6 with hydrazinium perchlorate, hydroxylammonium perchlorate, and methylammonium perchlorate

K. N. Trueblood, Carolyn B. Knobler, David S. Lawrence et al. · Journal of the American Chemical Society · 1982 · 86 citations

Natural Sciences, Chemistry, Crystal Structure +10

Structure‐Directed Synthesis under Thermodynamic Control: Macrocyclic Trimers from Cinchona Alkaloids

Stuart J. Rowan, Paul A. Brady, Jeremy K. M. Sanders · Angewandte Chemie International Edition in English · 1996 · 68 citations

Pharmacy, Chemistry, Medicinal Chemistry +13