Linkage between O6-methylguanine-DNA methyltransferase (O6-MT) activity and cellular resistance to antitumour nitrosoureas in cultured rat brain tumour cell strains

Randomized Comparisons of Radiotherapy and Nitrosoureas for the Treatment of Malignant Glioma after Surgery

Michael Walker, Sylvan B. Green, David P. Byar et al. · New England Journal of Medicine · 1980 · 1.6K citations

Medicine, Oncology, Radiation Oncology +9

Differentiated Rat Glial Cell Strain in Tissue Culture

Philippe Benda, J. Lightbody, Gordon Sato et al. · Science · 1968 · 1.5K citations

Medicine, Cell Biology, Neuroscience +9

DNA cross-linking and monoadduct repair in nitrosourea-treated human tumour cells

Leonard C. Erickson, Laurent Guy, Nancy A. Sharkey et al. · Nature · 1980 · 312 citations

Life Sciences, Molecular Biology, Oncology +16

Adaptive response to alkylating agents involves alteration in situ of O6-methylguanine residues in DNA

Peter Karran, Tomas Lindahl, Beverly E. Griffin · Nature · 1979 · 259 citations

Life Sciences, Genetics, Molecular Biology +13

Formation of the cross-link 1-[N3-deoxycytidyl),2-[N1-deoxyguanosinyl]ethane in DNA treated with N,N'-bis(2-chloroethyl)-N-nitrosourea.

William P. Tong, Marion Kirk, David B. Ludlum · PubMed · 1982 · 226 citations

Pharmacy, Molecular Biology, Bioorthogonal Chemistry +16