Detecting single base substitutions as heteroduplex polymorphisms

Rapid and sensitive detection of point mutations and DNA polymorphisms using the polymerase chain reaction

Masato Orita, Youichi Suzuki, Takao Sekiya et al. · Genomics · 1989 · 3.5K citations

Life Sciences, Genetics, Molecular Genetics +16

Principles of Nucleic Acid Structure

JH Parish · Biochemical Education · 1985 · 1.5K citations

Life Sciences, Biochemistry, Molecular Biology +12

Attachment of a 40-base-pair G + C-rich sequence (GC-clamp) to genomic DNA fragments by the polymerase chain reaction results in improved detection of single-base changes.

Val C. Sheffield, David R. Cox, Leonard S. Lerman et al. · Proceedings of the National Academy of Sciences · 1989 · 1.3K citations · Full text

Life Sciences, Genetics, Molecular Biology +14

A major segment of the neurofibromatosis type 1 gene: cDNA sequence, genomic structure, and point mutations

Richard Cawthon, Robert B. Weiss, Gangfeng Xu et al. · Cell · 1990 · 1.1K citations

Life Sciences, Genetics, Molecular Genetics +12

Reactivity of cytosine and thymine in single-base-pair mismatches with hydroxylamine and osmium tetroxide and its application to the study of mutations.

Richard G.H. Cotton, Nanda R. Rodrigues, R. Duncan Campbell · Proceedings of the National Academy of Sciences · 1988 · 625 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +14