Xanthene derived potent nonpeptidic inhibitors of recombinant human calpain I

Peptidyl (acyloxy)methyl ketones and the quiescent affinity label concept: the departing group as a variable structural element in the design of inactivators of cysteine proteinases

Allen Krantz, Leslie J. Copp, Peter J. Coles et al. · Biochemistry · 1991 · 143 citations

Protein Chemistry, Variable Structural Element, Bioorganic Chemistry +13

The design of peptidyldiazomethane inhibitors to distinguish between the cysteine proteinases calpain II, cathepsin L and cathepsin B

Cynthia A. Crawford, Robert W. Mason, P Wikström et al. · Biochemical Journal · 1988 · 138 citations · Full text

Bioorganic Chemistry, Aldo-keto Reductase, Chemical Biology +20

Stereospecific Synthesis of Peptidyl .alpha.-Keto Amides as Inhibitors of Calpain

Scott L. Harbeson, Susan M. Abelleira, Alan Akiyama et al. · Journal of Medicinal Chemistry · 1994 · 120 citations · Full text

Molecular Pharmacology, Medicinal Chemistry, Alpha-keto Amides +15

Peptide .alpha.-keto ester, .alpha.-keto amide, and .alpha.-keto acid inhibitors of calpains and other cysteine proteases

Zhaozhao Li, Girish S. Patil, Zbigniew E. Golubski et al. · Journal of Medicinal Chemistry · 1993 · 109 citations · Full text

Pharmaceutical Science, Bioorganic Chemistry, Aldo-keto Reductase +19

Inhibition of calpain in intact platelets by the thiol protease inhibitor E-64d

Eleanor B. McGowan, E Becker, Thomas C. Detwiler · Biochemical and Biophysical Research Communications · 1989 · 104 citations

Thrombopoiesis, Thrombosis, Biochemistry +12