Peter J. Coles

Peptidyl (acyloxy)methyl ketones and the quiescent affinity label concept: the departing group as a variable structural element in the design of inactivators of cysteine proteinases

Allen Krantz, Leslie J. Copp, Peter J. Coles et al. · Biochemistry · 1991 · 143 citations

Life Sciences, Biochemistry, Pharmacology +17

New inhibitors of cysteine proteinases. Peptidyl acyloxymethyl ketones and the quiescent nucleofuge strategy

Roger A. Smith, Leslie J. Copp, Peter J. Coles et al. · Journal of the American Chemical Society · 1988 · 65 citations

Life Sciences, Biochemistry, Chemistry +12

Comparative behaviour of calpain and cathepsin B toward peptidyl acyloxymethyl ketones, sulphonium methyl ketones and other potential inhibitors of cysteine proteinases

Diana H. Pliura, Bonnie J. Bonaventura, Roger A. Smith et al. · Biochemical Journal · 1992 · 50 citations · Full text

Life Sciences, Biochemistry, Pharmacology +17

Peptidyl O-acyl hydroxamates: Potent new inactivators of cathepsin B

Roger A. Smith, Peter J. Coles, Robin W. Spencer et al. · Biochemical and Biophysical Research Communications · 1988 · 35 citations

Life Sciences, Biochemistry, Medicinal Chemistry +11

In vivo Inhibition of Cathepsin B by Peptidyl (Acyloxy)methyl Ketones

Bonnie M. Wagner, Roger A. Smith, Peter J. Coles et al. · Journal of Medicinal Chemistry · 1994 · 30 citations

Medicine, Medicinal Chemistry, Pharmacology +12