P53 AND BCL-2 IMMUNOHISTOCHEMISTRY IN PRETREATMENT PROSTATE NEEDLE BIOPSIES TO PREDICT RECURRENCE OF PROSTATE CANCER AFTER RADICAL PROSTATECTOMY

Abstract

The p53 and bcl-2 biomarkers appear to be important to predict recurrence of prostate cancer when prostatectomy specimens are analyzed but this usefulness is not apparent with immunohistochemical staining of prostate biopsies. This difference may reflect sampling error and/or the heterogeneous nature of prostate cancers, and deserves further study.