Control of the T Follicular Helper–Germinal Center B-Cell Axis by CD8 ⁺ Regulatory T Cells Limits Atherosclerosis and Tertiary Lymphoid Organ Development

Abstract

This study is the first to demonstrate that the T follicular helper-germinal center B-cell axis is proatherogenic and that CD8(+) regulatory T cells control the germinal center reaction in both secondary and tertiary lymphoid organs. Therefore, disrupting this axis represents an innovative therapeutic approach.