Journal of the American Chemical Society · 2003 · 107 citations · 14 references
Natural SciencesBiochemistryChemistryBiocatalysisCatalysisNucleic Acid ChemistryCatalytic MechanismsDna ChemistryEnzymatic CatalysisEnzyme CatalysisMetal CatalysisOligonucleotide ChemistryComplementary Dna AmplificationDna Template RecognitionEnzymatic Catalysis MechanismsHeterogeneous Metal CatalysisSignal Amplification MechanismsTemplate Catalysis
Hydrolysis of an ester substrate by a CuII complex catalyst, both attached to oligo-peptide nucleic acids (PNA), is accelerated up to 485-fold in the presence of a complementary DNA template. The approach combines the sequence selectivity of DNA-templated reactions with signal amplification by multiple turnover and the versatility of metal catalysis.
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Structure of a Copper-Mediated Base Pair in DNA
S. Atwell, Eric Meggers, Glen Spraggon et al. · Journal of the American Chemical Society · 2001 · 248 citations
A formula for thermal stability (Tm) prediction of PNA/DNA duplexes
U. Giesen · Nucleic Acids Research · 1998 · 192 citations · Full text
Jean‐Christophe François, Tula Saison‐Behmoaras, Claudette Barbier et al. · Proceedings of the National Academy of Sciences · 1989 · 149 citations · Full text