Cyclooxygenase (COX)-1 Activity Precedes the COX-2 Induction in Aβ-Induced Neuroinflammation

beta-Amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity

MP Mattson, Bin Cheng, David L. Davis et al. · Journal of Neuroscience · 1992 · 1.6K citations · Full text

Life Sciences, Neurobiology, Neuroscience +17

Expression of a mitogen-inducible cyclooxygenase in brain neurons: Regulation by synaptic activity and glucocorticoids

Kanato Yamagata, Katrin I. Andreasson, Walter E. Kaufmann et al. · Neuron · 1993 · 1.2K citations

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Clinical trial of indomethacin in Alzheimer's disease

Jospeh Rogers, L. Kirby, S. R. Hempelman et al. · Neurology · 1993 · 999 citations

Medicine, Neurology, Pharmacology +15

Effects of rofecoxib or naproxen vs placebo on Alzheimer disease progression: a randomized controlled trial.

Paul Aisen, Kimberly Schafer, Michael Grundman et al. · PubMed · 2003 · 968 citations

Medicine, Pharmacology, Pharmacotherapy +17

Cyclooxygenase-2 is instrumental in Parkinson's disease neurodegeneration

Peter Teismann, Kim Tieu, Dong‐Kug Choi et al. · Proceedings of the National Academy of Sciences · 2003 · 659 citations · Full text

Life Sciences, Neurobiology, Neuroscience +17