A Novel High-Throughput Assay for Islet Respiration Reveals Uncoupling of Rodent and Human Islets

Abstract

The assay for islet respiration presented here provides a novel tool that can be used to study islet mitochondrial function in a relatively high-throughput manner. The data obtained in this study shows that rodent islets are less bioenergetically efficient than human islets as well as INS1 cells.