KCa3.1 potassium channels are critical for cAMP-dependent chloride secretion and cyst growth in autosomal-dominant polycystic kidney disease

The mTOR pathway is regulated by polycystin-1, and its inhibition reverses renal cystogenesis in polycystic kidney disease

Jonathan M. Shillingford, Noel Murcia, Claire H. Larson et al. · Proceedings of the National Academy of Sciences · 2006 · 798 citations · Full text

Medicine, Molecular Genetics, Nephrology +15

Inhibition of renal cystic disease development and progression by a vasopressin V2 receptor antagonist

Vincent H. Gattone, Xiaofang Wang, Peter C. Harris et al. · Nature Medicine · 2003 · 669 citations

Medicine, Nephrology, Pharmacology +8

Design of a potent and selective inhibitor of the intermediate-conductance Ca ²⁺ -activated K ⁺ channel, <i>IKCa1</i> : A potential immunosuppressant

Heike Wulff, Mark J. Miller, Wolfram Hänsel et al. · Proceedings of the National Academy of Sciences · 2000 · 606 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +13

Effective treatment of an orthologous model of autosomal dominant polycystic kidney disease

Vicente E. Torres, Xiaofang Wang, Qi Qian et al. · Nature Medicine · 2004 · 481 citations

Medicine, Genetics, Nephrology +14

Polycystin-1, STAT6, and P100 Function in a Pathway that Transduces Ciliary Mechanosensation and Is Activated in Polycystic Kidney Disease

Seng Hui Low, Shivakumar Vasanth, Claire H. Larson et al. · Developmental Cell · 2006 · 366 citations · Full text

Life Sciences, Cell Biology, Nephrology +13