8-oxoguanine causes spontaneous de novo germline mutations in mice

Rate of de novo mutations and the importance of father’s age to disease risk

Augustine Kong, Michael L. Frigge, Gísli Másson et al. · Nature · 2012 · 2.2K citations · Full text

Genetic Testing, Genetic Disorder, Genetics +7

Insertion of specific bases during DNA synthesis past the oxidation-damaged base 8-oxodG

Shinya Shibutani, Masaru Takeshita, Arthur P. Grollman · Nature · 1991 · 2.2K citations

Biosynthesis, Bioorganic Chemistry, Biochemistry +10

Inherited variants of MYH associated with somatic G:C→T:A mutations in colorectal tumors

Nada Al Tassan, Nikolas H. Chmiel, Julie Maynard et al. · Nature Genetics · 2002 · 1.4K citations

Tumor Biology, Somatic Variant, Inherited Variants +10

MutT protein specifically hydrolyses a potent mutagenic substrate for DNA synthesis

Hisaji Maki, Mutsuo Sekiguchi · Nature · 1992 · 890 citations

Natural Sciences, Genetics, Protein Biosynthesis +8

Cloning and characterization of <i>hOGG1</i> , a human homolog of the <i>OGG1</i> gene of <i>Saccharomyces cerevisiae</i>

J. Pablo Radicella, Claudine Dhérin, Chantal Desmaze et al. · Proceedings of the National Academy of Sciences · 1997 · 592 citations · Full text