Concepedia

Evolutionarily distinct bacteriophage endolysins featuring conserved peptidoglycan cleavage sites protect mice from MRSA infection

Mathias Schmelcher, Yang Shen, Daniel Nelson, Marcel R. Eugster, Fritz Eichenseher, Daniela C. Hanke, Martin J. Loessner, Shengli Dong, David G. Pritchard, Jean C. Lee,

Journal of Antimicrobial Chemotherapy · 2015 · 142 citations · 48 references

DOIFull text

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Abstract

Our results corroborate the high potential of PGHs for treatment of S. aureus infections and reveal unique antimicrobial and biochemical properties of the different enzymes, suggesting a high diversity of potential applications despite highly conserved peptidoglycan target sites.

References

48

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