Concepedia

Functional overlap in the cis-acting regulation of the V(D)J recombination at the TCRβ locus

Bernard Khor, Grace K. Mahowald, Katrina C. Khor, Barry P. Sleckman

Molecular Immunology · 2008 · 10 citations · 26 references

Open access

Concepts

Life SciencesImmunologyMolecular BiologyGene RegulationRecombinationSignal TransductionAntigen Receptor Gene RearrangementClass Switch RecombinationRecombination ProteinsRecombination RegulationV(d)j RecombinationCis-acting Regulatory ElementsRecombination Signal Sequence RecognitionRecombination Signal SequencesT-cell Receptor Gene Rearrangement FidelityV(d)j Recombination FidelityV(d)j Recombination MachineryV(d)j Recombination MechanismV(d)j Recombination Regulation

References

26

Somatic generation of antibody diversity

Susumu Tonegawa · Nature · 1983 · 4K citations

Life Sciences, Biotechnology, Immunology +14

Ordered rearrangement of immunoglobulin heavy chain variable region segments.

Frederick W. Alt, George D. Yancopoulos, T. Keith Blackwell et al. · The EMBO Journal · 1984 · 733 citations · Full text

Life Sciences, Immunology, Molecular Biology +12

Function of the TCRα Enhancer in αβ and γδ T Cells

Barry P. Sleckman, Christiana G. Bardon, Roger Ferrini et al. · Immunity · 1997 · 201 citations · Full text

Life Sciences, Immunology, Molecular Biology +14

Deletion of the mouse T-cell receptor beta gene enhancer blocks alphabeta T-cell development.

Gaëlle Bouvier, Françoise Watrin, Marianne Naspetti et al. · Proceedings of the National Academy of Sciences · 1996 · 176 citations

Life Sciences, Genetics, Immunology +17

Recombination signal sequences restrict chromosomal V(D)J recombination beyond the 12/23 rule

Craig H. Bassing, Frederick W. Alt, Maureen M. Hughes et al. · Nature · 2000 · 173 citations

Medicine, Genetics, Molecular Genetics +13