Muscle necrosis by N-methylated p-phenylenediamines in rats: Structure-activity relationships and correlation with free-radical production in vitro

Improved method for the determination of blood glutathione.

Ernest Beutler, Olga Duron, Barbara M. Kelly · PubMed · 1963 · 6.9K citations

Bioassay-guided Isolation, Medicine, Bioanalysis +5

MICRODETERMINATION OF OXYHEMOGLOBIN, METHEMOGLOBIN, AND SULFHEMOGLOBIN IN A SINGLE SAMPLE OF BLOOD

Kenneth A. Evelyn, Helga Tait Malloy · Journal of Biological Chemistry · 1938 · 1.2K citations · Full text

Laboratory Hematology, Biochemistry, Medicine +10

N-acetyl-p-benzoquinone imine: a cytochrome P-450-mediated oxidation product of acetaminophen.

David C. Dahlin, Gerald T. Miwa, Albert Lu et al. · Proceedings of the National Academy of Sciences · 1984 · 1.1K citations

Pharmacotherapy, Redox Biology, Pharmaceutical Chemistry +21

Purification and characterisation of prostaglandin endoperoxide synthetase from sheep vesicular glands

Frans J. van der Ouderaa, M. Buytenhek, D.H. Nugteren et al. · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · 1977 · 417 citations

Animal Physiology, Biosynthesis, Cellular Enzymology +11

The toxicity of acetaminophen and N-acetyl-p-benzoquinone imine in isolated hepatocytes is associated with thiol depletion and increased cytosolic Ca2+.

Matthew D. Moore, Hjördis Thor, Gregory Moore et al. · Journal of Biological Chemistry · 1985 · 411 citations · Full text

Ca2+ Homeostasis, Cell Death, Cytosolic Ca2+ +22