Antinociception by systemically-administered acetaminophen (paracetamol) involves spinal serotonin 5-HT7 and adenosine A1 receptors, as well as peripheral adenosine A1 receptors

Adenosine A1 receptors mediate local anti-nociceptive effects of acupuncture

Nanna Goldman, Michael Chen, Takumi Fujita et al. · Nature Neuroscience · 2010 · 803 citations · Full text

Nursing, Pharmacotherapy, Pain Management +12

Molecular cloning, characterization, and localization of a high-affinity serotonin receptor (5-HT7) activating cAMP formation.

Martial Ruat, Élisabeth Traiffort, Rob Leurs et al. · Proceedings of the National Academy of Sciences · 1993 · 617 citations

Medicine, Molecular Biology, Pharmacology +17

Binding of the A1-selective adenosine antagonist 8-cyclopentyl-1,3-dipropylxanthine to rat brain membranes

Robert F. Bruns, James H. Fergus, Edward W. Badger et al. · Naunyn-Schmiedeberg s Archives of Pharmacology · 1987 · 377 citations

Life Sciences, Neuroscience, Pharmacology +9

Central and peripheral antialgesic action of aspirin-like drugs

Sérgio H. Ferreira, B. B. Lorenzetti, Fernando Morgan de Aguiar Corrêa · European Journal of Pharmacology · 1978 · 375 citations

Medicine, Pharmacology, Pharmacotherapy +14

A Novel, Potent, and Selective 5-HT₇Antagonist:  (<i>R</i>)-3-(2-(2-(4-Methylpiperidin-1-yl)ethyl)pyrrolidine-1-sulfonyl)phenol (SB-269970)

Peter J. Lovell, Steven M. Bromidge, Steven Dabbs et al. · Journal of Medicinal Chemistry · 2000 · 249 citations · Full text

Medicine, Chemistry, Pharmacology +5