Synthesis, binding affinity and selectivity of new β1- and β2-adrenoceptor blockers

THE ATTRACTIONS OF PROTEINS FOR SMALL MOLECULES AND IONS

George Scatchard · Annals of the New York Academy of Sciences · 1949 · 19.9K citations

Natural Sciences, Biophysics, Chemistry +9

Relationship between the inhibition constant (KI) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

Yung-Chi Cheng, William H. Prusoff · Biochemical Pharmacology · 1973 · 12.9K citations

Life Sciences, Biochemistry, Chemical Kinetics +14

Differentiation of Receptor Systems activated by Sympathomimetic Amines

A.M. Lands, A. Arnold, J.P. McAuliff et al. · Nature · 1967 · 2.1K citations

Medicine, Pharmacology, Neuropharmacology +13

Cloning of the gene and cDNA for mammalian β-adrenergic receptor and homology with rhodopsin

Richard A. F. Dixon, Brian K. Kobilka, David J. Strader et al. · Nature · 1986 · 1.3K citations

Life Sciences, Biochemistry, Pharmacology +8

Molecular Characterization of the Human β ₃ -Adrenergic Receptor

Laurent J. Emorine, Stéfano Marullo, Marie‐M. BRIEND‐SUTREN et al. · Science · 1989 · 1.1K citations

Life Sciences, Biochemistry, Pharmacology +17