Self-quenching polysaccharide-based nanogels of pullulan/folate-photosensitizer conjugates for photodynamic therapy

A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs.

Yasuhiro Matsumura, Hiroshi Maeda · PubMed · 1986 · 6.8K citations

Medicine, Oncology, Pharmacology +12

Phase I clinical and pharmacokinetic study of PK1 [N-(2-hydroxypropyl)methacrylamide copolymer doxorubicin]: first member of a new class of chemotherapeutic agents-drug-polymer conjugates. Cancer Research Campaign Phase I/II Committee.

P. Vasey, Stan B. Kaye, Rachel Morrison et al. · PubMed · 1999 · 691 citations

Pharmacy, Pharmacokinetics, Pharmacology +16

The extracellular release of HMGB1 during apoptotic cell death

Charles W. Bell, Weiwen Jiang, Charles F. Reich et al. · American Journal of Physiology-Cell Physiology · 2006 · 534 citations

Life Sciences, Cell Biology, Molecular Biology +8

Nuclear delivery of doxorubicin via folate-targeted liposomes with bypass of multidrug-resistance efflux pump.

Dorit Goren, Aviva T. Horowitz, Dina Tzemach et al. · PubMed · 2000 · 402 citations

Pharmacy, Pharmaceutics, Pharmacology +17

Cellular localization of the folate receptor: potential role in drug toxicity and folate homeostasis.

Steven Weitman, Arthur G. Weinberg, Leslie R. Coney et al. · PubMed · 1992 · 335 citations

Medicine, Oncology, Pharmacology +12