Microbiology and Immunology · 1991 · 11 citations · 12 references
MedicineImmunologyPharmacologyImmunopathologyImmunotherapyInflammationAnti-inflammatory PharmacologyNeuroprotectionMechanisms Of Herb-drug InteractionPretreatmentRectal Temperature MeasurementTraditional Chinese MedicineTumor Necrosis Factor Inhibitor TherapyTumor Necrosis Factor Receptor 1 SignalingTumor Necrosis Factor Receptor SignalingTumor Necrosis Factor Therapy
We observed the effects of a chinese herb medicine Sho-saiko-to on the lethal and antitumor activities of recombinant human tumor necrosis factor (rhTNF) administered in mice. Sho-saiko-to was noted to protect the rhTNF-induced lethality in galactosamine-hypersensitized mice, and also Sho-saiko-to pretreated mice was protected against the decrease of rectal temperature after rhTNF administration. On the other hand, there was a remarkable enhancement of antitumor activity of rhTNF by Sho-saiko-to pretreatment. These results suggest that Sho-saiko-to drug may protect mice from severe shock syndrome induced by rhTNF.
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