μ-Opioid receptor knockout mice display reduced cocaine conditioned place preference but enhanced sensitization of cocaine-induced locomotion

Unresponsiveness to Cannabinoids and Reduced Addictive Effects of Opiates in CB ₁ Receptor Knockout Mice

Catherine Ledent, Olga Valverde, G Cossu et al. · Science · 1999 · 3.6K citations

Medicine, Neuroscience, Pharmacology +15

Loss of morphine-induced analgesia, reward effect and withdrawal symptoms in mice lacking the µ-opioid-receptor gene

Hans W. D. Matthes, Rafaël Maldonado, Frédéric Simonin et al. · Nature · 1996 · 1.7K citations

Medicine, Neuroscience, Pharmacology +17

Opiate receptor knockout mice define μ receptor roles in endogenous nociceptive responses and morphine-induced analgesia

Ichiro Sora, Nobuyuki Takahashi, Masahiko Funada et al. · Proceedings of the National Academy of Sciences · 1997 · 528 citations

Nursing, Pharmacology, Neuropharmacology +16

Cocaine self-administration in dopamine-transporter knockout mice

Beatriz Rocha, Fabio Fumagalli, Raul R. Gainetdinov et al. · Nature Neuroscience · 1998 · 524 citations

Life Sciences, Neurobiology, Neuroscience +14

Cocaine reward models: Conditioned place preference can be established in dopamine- and in serotonin-transporter knockout mice

Ichiro Sora, Christine H. Wichems, Nobuyuki Takahashi et al. · Proceedings of the National Academy of Sciences · 1998 · 510 citations

Medicine, Neuroscience, Pharmacology +17