PDZ Domain–Binding Motif Regulates Cardiomyocyte Compartment-Specific Na _V 1.5 Channel Expression and Function

Abstract

Our results demonstrate the in vivo significance of the PDZ domain-binding motif in the correct expression of NaV1.5 at the lateral cardiomyocyte membrane and underline the functional role of lateral NaV1.5 in ventricular conduction. Furthermore, we reveal a clinical relevance of the SIV motif in cardiac disease.