Nahuoic Acid A Produced by a <i>Streptomyces</i> sp. Isolated From a Marine Sediment Is a Selective SAM-Competitive Inhibitor of the Histone Methyltransferase SETD8 - Concepedia

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Nahuoic Acid A Produced by a <i>Streptomyces</i> sp. Isolated From a Marine Sediment Is a Selective SAM-Competitive Inhibitor of the Histone Methyltransferase SETD8

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Citations

8

References

2012

Year

David E. Williams, Doralyn S. Dalisay, Fengling Li, James T.M. Amphlett, Wisanu Maneerat, Miguel Angel Garcia Chavez, Yan Alexander Wang, Teatulohi Matainaho, Wenyu Yu, Peter J. Brown,

Organic Letters

Epigenetic ChangeMolecular BiologySecondary MetaboliteChemical BiologyEpigeneticsBiosynthesisNatural Product BiosynthesisHistone Methyltransferase Setd8BiotransformationBiochemistryMolecular MicrobiologyMarine SedimentGene ExpressionEpigenetic RegulationChromatin FunctionChromatinMarine BiotechnologyTropical Marine SedimentChromatin RemodelingNatural SciencesEpigenomicsSelective Sam-competitive InhibitorMicrobiologyMedicineNahuoic Acid A

Abstract

The histone lysine monomethyltransferase SETD8 is an epigenetic regulator of cell cycle progression. Nahuoic acid A (1), a polyketide produced in culture by a Streptomyces sp. obtained from a tropical marine sediment, is the first known selective SAM-competitive inhibitor of SETD8. The structure of nahuoic acid A (1) has been elucidated by chemical transformation and detailed analysis of spectroscopic data.

References

	Year	Citations

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