Concepedia

Tirucallic Acids Are Novel Pleckstrin Homology Domain-Dependent Akt Inhibitors Inducing Apoptosis in Prostate Cancer Cells

Aydee C. Estrada, Tatiana Syrovets, Kai Pitterle, Oleg Lunov, Berthold Büchele, Judith Schimana-Pfeifer, Thomas J. Schmidt, Samy A.F. Morad, Thomas Simmet

Molecular Pharmacology · 2009 · 76 citations · 35 references

DOI

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References

35

Automated docking using a Lamarckian genetic algorithm and an empirical binding free energy function

Garrett M. Morris, David S. Goodsell, Robert S. Halliday et al. · Journal of Computational Chemistry · 1998 · 10.8K citations

, , +17

MolDock:  A New Technique for High-Accuracy Molecular Docking

René Thomsen, Mikael H. Christensen · Journal of Medicinal Chemistry · 2006 · 2.3K citations

, , +16

A transforming mutation in the pleckstrin homology domain of AKT1 in cancer

John D. Carpten, Andrew L. Faber, Candice L. Horn et al. · Nature · 2007 · 1.3K citations

, , +12

Distinct roles of Akt1 and Akt2 in regulating cell migration and epithelial–mesenchymal transition

Hanna Y. Irie, Rachel V. Pearline, Dorre A. Grueneberg et al. · The Journal of Cell Biology · 2005 · 590 citations · Full text

, , +17

Allosteric Akt (PKB) inhibitors: discovery and SAR of isozyme selective inhibitors

Craig W. Lindsley, Zhijian Zhao, William Leister et al. · Bioorganic & Medicinal Chemistry Letters · 2004 · 501 citations · Full text

, , +14