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Orthotopic liver transplantation in the rat. Technique using cuff for portal vein anastomosis and biliary drainage.
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1979
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Donor Rat LiverOrthotopic Liver TransplantationTissue TransplantationVisceral SurgerySurgeryBiomedical EngineeringCuff TechniquesOrgan PreservationArtificial OrganVascular SurgeryBiliary DisorderTransplantation SurgeryIntestinal TransplantationXenotransplantationLiver PhysiologyBiliary DrainageLiver TransplantationPortal VeinHepatologyBiliary TractTransplant SurgeryLiverMedicinePortal Vein AnastomosisAnesthesiology
Cuff techniques have been developed for portal vein and bile duct anastomoses in rat orthotopic liver transplantation. The study aims to evaluate the cuff method for portal vein anastomosis after machine preservation of donor rat livers. The cuff method shortens portal vein clamping time, reduces biliary complications, improves graft survival (83 % at 1 week, some >6 months), and simplifies microvascular anastomoses.
In orthotopic liver transplantation in the rat, cuff techniques have been developed for anastomoses of the portal vein and bile duct. These techniques have shortened the clamping time of the portal vein and have resulted in fewer biliary complications improving survival of the liver graft. Eighty-three per cent of the grafted animals have survived for 1 week and several animals have survived for more than 6 months. We believe that use of the cuff method technically simplifies microvascular anastomoses. It may be particularly useful for anastomosis of the portal vein after machine preservation of the donor rat liver.