Concepedia

Agents that cause DNA double strand breaks lead to p16INK4a enrichment and the premature senescence of normal fibroblasts

Steven J. Robles, Guy R. Adami

Oncogene · 1998 · 491 citations · 0 references

Concepts

Life SciencesGeneticsMolecular BiologyCarcinogenesisDna RepairEpigeneticsCellular SenescenceDna Damage SignalingDna Damage-induced ApoptosisDna Double-strand Break RepairDna Strand BreaksDouble-strand Break RepairDna Damage-induced SenescenceDna Double-strand BreaksDouble-strand Break-induced ApoptosisDouble-strand Dna BreaksP16ink4a PathwayP16ink4a RegulationSenescence