Group I and II mammalian PAKs have different modes of activation by Cdc42

Expression of Constitutively Active α-PAK Reveals Effects of the Kinase on Actin and Focal Complexes

Edward Manser, Huang Hai-yang, Tsui-Han Loo et al. · Molecular and Cellular Biology · 1997 · 559 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +15

Structure of PAK1 in an Autoinhibited Conformation Reveals a Multistage Activation Switch

Ming Lei, Wange Lu, Wuyi Meng et al. · Cell · 2000 · 546 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +14

PAK4, a novel effector for Cdc42Hs, is implicated in the reorganization of the actin cytoskeleton and in the formation of filopodia

Arie Abo, Jian Qu, Marta S. Cammarano et al. · The EMBO Journal · 1998 · 354 citations

Life Sciences, Cell Biology, Molecular Biology +14

Small-molecule p21-activated kinase inhibitor PF-3758309 is a potent inhibitor of oncogenic signaling and tumor growth

Brion W. Murray, Chuangxing Guo, Joseph Piraino et al. · Proceedings of the National Academy of Sciences · 2010 · 321 citations · Full text

Medicine, Oncology, Pharmacology +15

A Conserved Negative Regulatory Region in αPAK: Inhibition of PAK Kinases Reveals Their Morphological Roles Downstream of Cdc42 and Rac1

Zhou-shen Zhao, Edward Manser, Xiangqun Chen et al. · Molecular and Cellular Biology · 1998 · 319 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +11